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A NASAL COMPOSITION CONTAINING SEA WATER AS STABILITY-IMPROVING EXCIPIENT
专利权人:
发明人:
Zdravka Znezevic,Nina Popovic,Silvija Kamber,Marina Mavrinac
申请号:
US15537977
公开号:
US20170348230A1
申请日:
2014.12.24
申请国别(地区):
US
年份:
2017
代理人:
摘要:
A nasal composition of improved stability, its use, and process for production. The nasal composition consists of: xylometazoline hydrochloride (1), 0.01-0.1% w/w ipratropium bromide (2), 0.01-0.1% w/w and pharmaceutical excipients required to form final dosage forms selected from the group consisting of: nasal drops, liquid nasal sprays, or nasal washes. The nasal composition includes the content of purified sea water as a functional, stability-improving excipient, in amounts of 5-25% w/w. The nasal composition has an osmolality within the range 270-820 mOsm/kg, the pH value within the range 3-7, preferably within the range 3-4.2 or 5.8-7.0, and most preferably within the range 3.2-4.2 where it shows improved stability.
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