Paul Greengard,Gen He,Peng Li,Wenjie Luo,Lawrence P. Wennogle
申请号：
US13367049
公开号：
US20130149309A1
申请日:
2012.02.06
申请国别(地区):
US
年份:
2013
代理人:
摘要：
The invention provides a previously uncharacterized protein (gamma secretase activating protein or gSAP) that activates γ-secretase to produce β-amyloid protein (Aβ). Deposition of Aβ has been associated with Alzheimers disease and other pathologies. The invention thus additionally provides, e.g., screening methods and novel research tools, inhibitors of this novel protein, and methods of diagnosis, treatment and control of Alzheimers disease and other neurodegenerative conditions associated with deposition of Aβ.
