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PEPTIDE DENDRIMERS COMPRISING FIBRINOGEN-BINDING PEPTIDES
专利权人:
发明人:
申请号:
HK17101363.8
公开号:
HK1227708A
申请日:
2017.02.08
申请国别(地区):
HK
年份:
2017
代理人:
摘要:
Peptide dendrimers and agents are described, which can be used for polymerising fibrinogen and as haemostatic agents. The peptide dendrimers comprise a branched core, and a plurality of fibrinogen-binding peptides separately covaientiy attached to the branched core. The branched core comprises: i) from two to ten multi-functional amino acid residues, wherein each fibrinogen-binding peptide is separately covaientiy attached to a multi-functional amino acid residue of the branched core il) a plurality of multi-functional amino acid residues, wherein one or more fibrinogen-binding peptides are separately covaientiy attached to each of at least two adjacent multi-functional amino acid residues of the branched core Hi) a plurality of multi-functional amino acid residues, wherein two or more fibrinogen-binding peptides are separately covaientiy attached to at least one of the multi-functional amino acid residues of the branched core iv)a plurality of multi-functional amino acid residues, wherein two or more multi-functional amino acid residues are covaientiy linked through a side chain of an adjacent multi-functional amino acid residue or y) a single multi-functional amino acid residue, and a fibrinogen-binding peptide is separately covaientiy attached to each functional group of the multi-functional amino acid residue, The. multi-functional amino acid residues comprise tri- or tetra-functional amino acid residues, or tri- and tetra-functional amino acid residues, or the single mu!ti-funetionai amino acid residue is a tri- or tetra-functional amino acid residue.La présente invention concerne des dendrimères et des agents peptidiques qui peuvent être utilisés pour la polymérisation de fibrinogènes et en tant quagents hémostatiques. Les dendrimères peptidiques comprennent un noyau ramifié et une pluralité de peptides se liant à un fibrinogène séparément liés de façon covalente au noyau ramifié. Le noyau ramifié comprend : i) de deux à dix résidus dacide aminé multi-fonction
来源网站:
中国工程科技知识中心
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http://www.ckcest.cn/home/

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