A mielóma multiplex és a mielóma indukált csontreszorpció kezelése integrin antagonistákkal

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专利权人:

THE UNIVERSITY OF TEXAS SYSTEM;BOARD OF REGENTS

发明人:

MUNDY, GREGORY R.,YONEDA, TOSHIYUKI

申请号：

HU0103630

公开号：

HU229038B1

申请日:

1999.09.13

申请国别(地区):

HU

年份:

2013

代理人:

摘要：

Antagonists of alpha4 integrin/alpha4 integrin ligand adhesion, which inhibit the biological effects of such adhesion are described and methods for their use are detailed. Such antagonists are useful in suppressing bone destruction associated with multiple myeloma. The homing of multiple myeloma cells to bone marrow and their alpha4 integrin-dependent release of bone-resorbing factors, resulting in bone destruction in patients with multiple myeloma, is inhibited.

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