MURPHY, ANDREW J.,莫菲 安德鲁,莫菲 安德魯,PAPADOPOULOS, NICHOLAS J.,帕帕多普洛斯 尼古拉斯,ORENGO, JAMIE M.,奥伦哥 杰米,奧倫哥 傑米,莫菲 安德鲁,莫菲 安德魯,帕帕多普洛斯 尼古拉斯,奥伦哥 杰米,奧倫哥 傑米
申请号：
TW103108304
公开号：
TW201522370A
申请日:
2014.03.11
申请国别(地区):
TW
年份:
2015
代理人:
摘要：
The present invention provides antibodies that bind to interleukin-33 (IL-33) and methods of using the same. The invention includes antibodies that inhibit or attenuate IL-33-mediated signaling. The antibodies of the invention may function to block the interaction between IL-33 and ST2. Alternatively, certain antibodies of the invention inhibit or attenuate IL-33-mediated signaling without blocking the IL-33/ST2 interaction. According to certain embodiments of the invention, the antibodies are fully human antibodies that bind to human IL-33 with high affinity. The antibodies of the invention are useful for the treatment of diseases and disorders associated with IL-33 signaling and/or IL-33 cellular expression, such as inflammatory diseases, or allergic diseases.本發明係提供與介白素-33(IL-33)結合之抗體及其使用方法。本發明包括抑制或減弱IL-33-媒介的訊號傳遞之抗體。本發明之抗體可進行阻斷IL-33和ST2間交互作用。另外，特定的本發明抗體係在無阻斷IL-33/ST2相互作用下，抑制或減弱IL-33-媒介的訊號傳遞。根據特定的本發明實施例，此等抗體為以高親和力與人類IL-33結合之全人類抗體。本發明之抗體可用於治療與IL-33訊號傳遞及/或IL-33細胞表現有關的疾病和病症，例如發炎性疾病或過敏性疾病。
