simple variable domain, multispecific ligand, tnfr1, and tnf-alpha receptor antagonists, use of tnfr agonist, anti-tnfr1 antagonist, polypeptide or multispecific ligand, method for treating and / or preventing a condition or disease, nucleic acid, vector and host

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专利权人:

GLAXO GROUP LIMITED

发明人:

ADRIANNS ALLART STOOP,ARMIN SEPP,CAROLYN ENEVER,HAIQUN LIU,OLIVER SCHON,STEPHEN DUFFIELD

申请号：

BRPI1008014

公开号：

BRPI1008014A2

申请日:

2010.02.17

申请国别(地区):

BR

年份:

2016

代理人:

摘要：

The invention relates to anti-TNFR1 polypeptides, antibody single variable domains (dAbs), antagonists and multispecific ligands, as well as methods and uses of these. The anti-TNFR1 polypeptides, antibody single variable domains (dAbs), antagonists and multispecific ligands are useful for treating and/or preventing inflammatory disease, such as arthritis or COPD, as well as for pulmonary administration, oral administration, delivery to the lung and delivery to the GI tract of a patient.

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