GENETICS INSTITUTE, LLC; LLC;DANA-FARBER CANCER INSTITUTE, INC.;GENETICS INSTITUTE
发明人:
GORDON J. FREEMAN,CLIVE WOOD
申请号：
PT00959394
公开号：
PT1210428E
申请日:
2000.08.23
申请国别(地区):
PT
年份:
2015
代理人:
摘要：
The invention identifies PD-1 as a receptor for B7-4. B7-4 can inhibit immune cell activation upon binding to an inhibitory receptor on an immune cell. Accordingly, the invention provides agents for modulating PD-1, B7-4, and the interaction between B7-4 and PD-1 in order to modulate a costimulatory or an inhibitory signal in an immune cell resulting in modulation of the immune response.
