A biomedical and pharmaceutical waste sterilization system with an ozone injection system includes a vessel including a treatment chamber, wherein the vessel is disposed in an open frame for support thereof and the vessel includes an opening on a top side configured to receive biomedical waste and a shredding system to treat the biomedical waste and a circulation loop configured to provide water and ozone injection into the water into the treatment chamber and to receive water from the treatment chamber during a treatment cycle for the biomedical waste.
