LI Xin (CN),ЛИ Синь (CN),FENG Binqiang (CN),ФЭН Биньцян (CN),CHEN Yang (CN),ЧЭНЬ Ян (CN),LIU Tao (CN),ЛЮ Тао (CN),HE Feng (CN),ХЭ Фэн (CN),HE Mingxun (CN),ХЭ Минсюнь (CN),TAO Weikang (CN),ТАО Вэйкан (
申请号：
RU2018115569
公开号：
RU0002733373C2
申请日:
2016.09.30
申请国别(地区):
RU
年份:
2020
代理人:
摘要：
FIELD: organic chemistry.SUBSTANCE: present invention relates to a compound of formula (I):or a tautomer thereof, a mesomer, a racemate, an enantiomer, a diastereomer, or a mixture thereof, or a pharmaceutically acceptable salt thereof. To compound of formula (I) ring A is selected from a group consisting of C3-6 cycloalkyl and 5–6-member heterocyclyl containing one nitrogen atom or one oxygen atom； R is selected from unsubstituted 5–6-member heteroaryl containing one nitrogen atom； each R1 is identical to the other or different from it, and each is independently selected from a group consisting of a hydrogen atom and a halogen atom； each R2 is identical or different from the other and each is independently selected from a group consisting of a hydrogen atom, C1-6 alkyl, C1-6 alkoxy, hydroxyl, oxo, =CH2 and =CH-CN, where each of C1-6 alkyl and C1-6 alkoxy are optionally substituted with one or more groups selected from a group consisting of deuterium, C1-6 alkyl, a halogen atom, cyano, C1-6 alkoxy and C3-6 cycloalkyl； or two R2 together form unsubstituted 5–6 membered heterocyclyl containing two sulfur atoms or two oxygen atoms； p and q each independently represent 0, 1 or 2. Also disclosed is a method of producing a compound of formula (I), a pharmaceutical composition and use of compound (I).EFFECT: technical result: disclosed is an oxaspiroderivative compound of general formula (I), which can be used as a MOR receptor agonist (μ-opioid receptor).14 cl, 8 tbl, 31 exНастоящее изобретение относится к области органической химии, а именно к соединению формулы (I):или его таутомеру, мезомеру, рацемату, энантиомеру, диастереомеру, или их смеси, или их фармацевтически приемлемой соли. В соединение формулы (I) кольцо A выбрано из группы, состоящей из C3-6 циклоалкила и 5-6-членного гетероциклила, содержащего один атом азота или один атом кислорода； R выбран из незамещенного 5-6-членного гетероарила, содержащего один атом азота； каждый R1 идентичен другому или отличается о
