A modified oligonucleotide indicated by nucleotide sequence GxHyNz, wherein G is at least one selected from the group consisting of 2-deoxyguanosine, guanosine, 2-O-methylguanosine, 2-F guanosine, LNA (locked nucleic acid ) guanosine, deoxyguanosine and D-D-guanosine H is a unique nucleic acid guanosine N is at least one selected from the group consisting of 5-fluorodeoxycytidine, 5-fluorocytidine, 5- yododesoxicitidina, 5-iodocytidine, cytosine arabinoside / Ara-C, 2 , 2-difluorodeoxycytidine / gemcitabine and capecitabine, where G , M, N are distributed randomly x is an integer from 1 to 30, y is an integer from 0 to 30, z is an integer from 1 to 30, wherein the sum of (x + y + z) is not greater than 60, wherein the modified oligonucleotide is selected from SEQ ID Nos 1, 2, 3, 4, 6, 7, 13, 18, 23, 24, 29, 30, 31, 34, 35, 36, 37, 38, 39, 40, 41 , 42, 43, 44, 45, 46, 47.Un oligonucleótido modificado indicado por la secuencia nucleotídica GxHyNz, en donde G es al menos uno seleccionado del grupo que consiste en 2-desoxiguanosina, guanosina, 2-O-metilguanosina, 2-F-guanosina, LNA (ácido nucleico bloqueado)-guanosina, D-desoxiguanosina y D-guanosina H es un ácido nucleico exclusivo de guanosina N es al menos uno seleccionado del grupo que consiste en 5-fluorodesoxicitidina, 5-fluorocitidina, 5- yododesoxicitidina, 5-yodocitidina, arabinósido de citosina/Ara-C, 2,2-difluorodesoxicitidina/gemcitabina y capecitabina, en donde G, H, N se distribuyen al azar x es un entero de 1 a 30, y es un entero de 0 a 30, z es un entero de 1 a 30, en donde la suma de (x + y + z) no es mayor que 60, en donde el oligonucleótido modificado se selecciona de las SEQ ID n.os 1, 2, 3, 4, 6, 7, 13, 18, 23, 24, 29, 30, 31, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47.
