Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-2 proteins, compositions containing the compounds and methods of treating diseases during which is expressed anti-apoptotic Bcl-2 protein.L'invention concerne des composés qui inhibent l'activité de protéines Bcl-2 anti-apoptotiques, des compositions contenant ces composés et des méthodes de traitement de maladies dans lesquelles la protéine Bcl-2 anti-apoptotique est exprimée.