SINGH, SANJAYA,HUANG, DANYANG,FUNG, SEK, CHUNG, MICHAEL
申请号：
MX2011007343
公开号：
MX338940B
申请日:
2004.07.29
申请国别(地区):
MX
年份:
2016
代理人:
摘要：
The present invention relates to novel peptide epitopes derived from the CH3 domain of IgE which are recognized by high affinity antibodies that specifically bind IgE. These novel peptides may be used for both active immunization of a subject by administering these peptides to generate high affinity antibodies in a subject, as well as for generating high affinity anti-IgE antibodies in non-human hosts that specifically bind to these regions of IgE for passive immunization of a subject.La presente invención se refiere a un anticuerpo aislado o un fragmento que se une al antígeno del mismo, que comprende una región variable de cadena liviana que comprende CDRL1, CDRL2 y CDRL3 y una región variable de cadena pesada que comprende CDRH1, CDRH2 y CDRH3, en donde CDRL1consiste de la SEQ ID NO: 5, CDRL2 consiste de la SEQ ID NO: 6, CDRL3 consiste de la SEQ ID NO: 78, CDRH1 consiste de la SEQ ID NO: 15, CDRH2 consiste de la SEQ ID NO: 25 y CDRH3 consiste de la SEQ ID NO: 26, en donde el anticuerpo se une específicamente a IgE.
