Described herein are combinations including a therapeutically effective amount of an antiviral agent or a pharmaceutically acceptable salt, hydrate or solvate thereof and a therapeutically effective amount of a multiple sclerosis drug or a pharmaceutically acceptable salt, hydrate or solvate thereof and pharmaceutical compositions thereof. Also described herein are methods for the treatment and/or prevention of various diseases and disorders including multiple sclerosis (MS) and viral infections with a therapeutically effective amount of an antiviral agent or a pharmaceutically acceptable salt, hydrate or solvate thereof or a pharmaceutical composition thereof or the combinations above, or pharmaceutical compositions thereof and methods for the manufacture of these pharmaceutical compositions.
