A composition comprising a small molecule therapeutic agent and an organic acid compound is described. The small molecule therapeutic agent (i) has a water solubility at room temperature of less than about 1.0 g/L and (ii) is a base. The organic acid is one that (i) has a water solubility at room temperature of between 0.1 and 10 or of less than about 20 g/L, (ii) has a molar mass of less than 500 grams per mole, and/or (iii) maintains a pH of the composition when hydrated in its environment of use of between 3.0-6.5 for a period of at least about 30 days. The organic acid, particularly when it is present in the composition in stoichiometric excess, improves solubility of the small molecule therapeutic agent to provide a composition that delivers the therapeutic agent for a sustained period of time.
