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Compounds that inhibit MPS1 kinase
专利权人:
Cancer Research Technology Limited
发明人:
Swen Hoelder,Julian Blagg,Savade Solanki,Hannah Woodward,Sebastien Naud,Vassilios Bavetsias,Peter Sheldrake,Paolo Innocenti,Kwai-Ming J. Cheung,Butrus Atrash
申请号:
US15864499
公开号:
US10479788B2
申请日:
2018.01.08
申请国别(地区):
US
年份:
2019
代理人:
摘要:
The present invention relates to compounds of formula Iwherein R1, R4, Ar, W, X and Z are all as defined herein. The compounds of the present invention are known to inhibit the spindle checkpoint function of Monospindle 1 (Mps1—;also known as TTK) kinases either directly or indirectly via interaction with the Mps1 kinase itself. In particular, the present invention relates to the use of these compounds as therapeutic agents for the treatment and/or prevention of proliferative diseases, such as cancer. The present invention also relates to processes for the preparation of these compounds, and to pharmaceutical compositions comprising them.
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