Jacques F. Banchereau,Gerard Zurawski,Anne-Laure Flamar,Amanda Cobb,Holly Mead,Monica Montes,Sandra Zurawski,SangKon Oh
申请号：
US12504463
公开号：
US09109011B2
申请日:
2009.07.16
申请国别(地区):
US
年份:
2015
代理人:
摘要：
The present invention includes compositions and methods for making and using a vaccine that includes a DC-specific antibody or fragment thereof to which an engineered Gag antigen is attached to form an antibody-antigen complex, wherein the Gag antigen is less susceptible to proteolytic degradation by eliminating one or more proteolytic sites or a DC-specific antibody or fragment thereof to which an engineered Nef antigen is attached to form an antibody-antigen complex, wherein the Nef antigen comprises one or more codon usage optimization that increase antibody-antigen complex secretion, or both, wherein the vaccine is able to elicit an HIV-specific T cell immune response to Gag p17, Gag p24, Nef and/or Cyclin D1.
