Audio processing devices and methods. An ambient microphone picks up ambient sound and a voice microphone picks up a speakers voice. The voice microphone is located farther from the speakers mouth when a device is held to one side of the speakers face than when held to the other side. A signal indicates whether an expected position of the handheld body is a position on a left side or right side of a speakers face. Ambient sound in the voice signal is reduced by applying a first algorithm configuration selected to process voice signals with lower signal-to-noise ratio when the expected position in on one side of the speakers face, and by applying a second sound cancellation algorithm configuration selected to process higher signal-to-noise ratios when the expected position is on the other side of the speakers face.
