The present invention relates to a composition for preventing hair loss, and more specifically, a compound having a structure in which minoxidil and a peptide are chemically linked, and a pharmaceutical composition or cosmetic composition for preventing hair loss or promoting hair growth comprising the same. Related to things. The compound having a structure in which the minoxidil and peptide of the present invention are chemically linked not only has excellent physiological activities such as improvement of hair loss, promotion of hair growth, promotion of cell growth, etc., but also stability in water. Since it is excellent, it may be usefully used as a composition for preventing hair loss and promoting hair growth.本発明は、脱毛防止用組成物に関し、より詳細には、ミノキシジルとペプチドが化学的に連結された構造を有する化合物、及びこれを含む脱毛防止又は発毛促進用薬学的組成物又は化粧料組成物に関する。本発明のミノキシジルとペプチドが化学的に連結された構造を有する化合物は、脱毛の改善、発毛の促進、細胞成長の促進などのような生理活性に優れるだけでなく、水での安定性に優れるので、脱毛防止及び発毛促進用組成物として有用に用いられてよい。