#$%^&*AU2019216626A120190905.pdf#####C: Interwo n NRPortbl DCC DAR 19164595_l.docx-8/08/2019 ABSTRACT This invention relates to a prodrug of the monophosphate nucleotide of the wellknown oncology drug gemcitabine. Specifically, it relates to gemcitabine-[phenylbenzoxy-L-alaninyl)]-phosphate when present as a single phosphate diastereoisomer and, in particular, it relates to the (S)-phosphate diastereoisomer which offers a remarkable and unexpected increase in solubility relative to the (R)-diastereoisomer. The (S)phosphate epimer is also preferentially taken up into cyclodextrin solutions over the (R)diastereoisomer.WO 2015/198058 PCT/GB2015/051857 x"A'll Ao 6 mm 4O 4 . N . 1 4 X4 <； 4 % 4)oma 4A 4dO Fl0 .3
