The present invention relates to neurostimulation, and in particular relates to methods and devices for optimising or revising neurostimulation paradigms in response to changes in medication dosages or changed medication responses.
#$%^&*AU2020100330A420200910.pdf#####Abstract A system for delivering electrical neurostimulation therapy concurrently with a medicament regime involving changing or titrating electrical neurostimulation in response to changed medication. The system comprising: a neuromodulation device to deliver the electrical neurostimulation therapy, measurement circuitry configured to capture recordings of neural responses evoked by the electrical neurostimulation therapy, a processor configured to process the recordings of the neural responses in order to obtain a plurality of measures of neural activation in response to a plurality of stimuli delivered over time, the processor further configured to revise the stimulus parameter in order to maintain neural activation within a target therapeutic window, the processor further configured to adjust bounds of the target therapeutic window in response to an indicia of a change in the medicament regime.150 192 100 110 Fig. 1 ELECTRODE 110 ELECTRODE SELECTION 126 POWER PULSE AMPLIFIER & I 150 SOURCE GENERATOR ADC 112 124 128 TELEMETRY MODULE CONTROLLER I114 116 CLINICAL SETTINGS, I 11 DATA PROGRAM I 120 122 100 Fig. 2
