The present invention provides an immune cell (CAR-T cell, etc.) that has higher antitumor activity than immune cells (CAR-T cell, etc.) that express CAR alone (do not express cytokines and / or chemokines). T cell expression provided in one aspect of the present invention (1) chimeric antigen receptor (CAR), (2) selected from interleukin-15 (IL-15), interleukin-18 (IL-18 ), At least one of the group consisting of interleukin-21 (IL-21) and interleukin-27 (IL-27), and (3) CC chemokine ligand 19 (CCL19).本發明提供一種抗腫瘤活性高於單獨表現CAR(不表現細胞激素及/或趨化因子)之免疫細胞(CAR-T細胞等)的免疫細胞(CAR-T細胞等)。本發明之一態樣中所提供之T細胞表現(1)嵌合抗原受體(CAR)、(2)選自由介白素-15(IL-15)、介白素-18(IL-18)、介白素-21(IL-21)及介白素-27(IL-27)所組成之群中之至少1種、以及(3)CC趨化因子配體19(CCL19)。
