The present disclosure relates to lipoprotein complexes and lipoprotein populations and their use in the treatment and/or prevention of dyslipidemic diseases, disorders, and/or conditions. The disclosure further relates to recombinant expression of apolipoproteins, purification of apolipoproteins, and production of lipoprotein complexes using thermal cycling-based methods.本發明係關於脂蛋白複合物及脂蛋白群體,及其於治療及/或預防脂質異常性疾病、病症及/或病狀中之用途。本發明另外係關於脂蛋白元之重組表現、脂蛋白元之純化及使用基於熱循環之方法產生脂蛋白複合物。