Synthetic FMD peptide immunogens and compositions containing the same are disclosed. Methods for detecting, treating, and preventing an FMD infection in an animal using the synthetic FMD peptide immunogens are also disclosed. In a specific embodiment, a peptidebased emergency vaccine and formulations thereof against Foot and Mouth Disease is described. Various vaccine formulations contain a mixture of peptides derived from FMDV VP1 protein； each peptide containing a B cell FMDV neutralizing/receptor binding epitope sequence linked to an artificial Th epitope to enhance the immunogenicity of each peptide. Disclosed vaccine formulations containing viral immunogens can optionally be supplemented with a mixture of peptides representing the FMDV endogenous Th epitopes derived from FMDV proteins, homologues and functional analogues thereof. Such viral peptide compositions are prepared in an acceptable delivery system as vaccine formulations and can provide protection pigs and cattle from infection upon FMDV challenge with only single administration.本發明提供一種合成FMD胜肽免疫原與其組成物，以及使用FMD胜肽免疫原偵測、治療與抑制FMD感染的方法。在一特定實施例中，本發明提供一種口蹄疫的胜肽緊急疫苗及其配方。本發明疫苗配方含有FMDV VP1蛋白胜肽混合物，各個含B細胞FMDV中和/受體結合抗原決定位序列的胜肽連接至一人工Th抗原決定位，以促進各胜肽的免疫原。本發明之疫苗配方含有病毒免疫原，可選擇性地輔以具有FMDV內源性Th抗原決定位的混合物、同源物及其功能類似物。本發明病毒胜肽組成物可與可接受之傳遞系統製成一疫苗配方，此在僅接種1次的情況下可保護豬、牛抵抗FMDV攻毒。
