ГЕЙВИН Пол Дейвид (AU),ЭЛЬ-ТАМИМИ Махмуд (AU),ЛИБИНАКИ Роксан (AU),МОЗАФАРИ Мохаммад Реза (AU)
申请号：
RU2012133467/15
公开号：
RU2012133467A
申请日:
2011.02.04
申请国别(地区):
RU
年份:
2014
代理人:
摘要：
1. The composition of the carrier for the delivery of a biologically active compound containing a phosphate compound of an electron transfer agent selected from the group consisting of mono (tocopheryl) phosphate, monosodium salt of mono (tocopheryl) phosphate, disodium salt of mono (tocopheryl) phosphate, di (tocopheryl) phosphate monosodium salt of di (tocopheryl) phosphate or mixtures thereof, and a solvent selected from the group consisting of N, N-dimethylformamide (DMF), N-methyl-2-pyrrolidone (NMP), dimethyl sulfoxide (DMSO), N, N- dimethylacetamide (DMAC), dioxane, hexamethylphosphoric triamide, propyl carbonate, gamma-butyrolactone, acetic acid monomethyl ester, ethyl lactate, 1,3-dimethyl-2-imidazolidinone (dimethyl isosorbide or DMI), isopropyl myristate, propylene glycol ricinoleate, isononyl isonopropyl isopropyl isopropyl di isopropyl isopropyl diisopropylamino-isopropylamino-isopropylamino-isopropylamino oils, octyl palmitate, cetillactate, glycerol, caprylyl glycol, squalene, bisabolol, benzyl alcohol, cetyl ricinoleate, cetyl acetate, wheat germ glycerides, myristillact a, decyl oleate, isopropyl lanolate, pentaerythrityl tetrastearate, dicaprylate / dicaprate neopentylglycol, isononyl isononanoate * izotridetsilizononanoata, myristyl myristate, octyldodecanol and oktilgidroksistearata, wherein the solvent concentration is from about 0.05 to about 30 wt%. of the total concentration of the carrier composition. 2. The carrier composition according to claim 1, in which the tocopheryl phosphate is in a non-neutralized form. The carrier composition according to claim 2, in which the pH of the non-neutralized tocopheryl phosphate is from about 2 to about 4, from about1. Композиция носителя для доставки биологически активного соединения содержащая фосфатное соединение агента передачи электронов, выбранное из группы, у состоящей из моно(токоферил)фосфата, мононатриевой соли моно(токоферил)фосфата, динатриевой соли моно(токоферил)фосфата, ди(токоферил)фосфат
