KOH, HUN YEONG,고훈영,LEE, HAI WHANG,이해황,KONG, JAE YANG,공재양,PARK, WOO KYU,박우규,LEE, HEE YOON,이희윤,KWAK, JU MYUNG,곽주명,POPATRAO LANDGE KAMALKISHOR,포파트라오 랭귀, 카말키숄,SEO, YONG WAN,서용완,CHOI, JUNG HWA,최정화,CHOI, JA
申请号：
KR1020120021632
公开号：
KR1020130100442A
申请日:
2012.03.02
申请国别(地区):
KR
年份:
2013
代理人:
摘要：
PURPOSE: A 1-phenyl-4-(1,2,3-triazole-1-ylalkyl)piperazine derivative and a pharmaceutically acceptable salt thereof are provided to have excellent affinity to dopamine D4 receptor.CONSTITUTION: A 1-phenyl-4-(1,2,3-triazole-1-ylalkyl)piperazine compound of chemical formula 1 with stereoselectivity or a pharmaceutically acceptable salt thereof is provided. The pharmaceutically acceptable salt is generated by a reaction with inorganic acids, organic acids, amino acids, sulfonic acids, alkali metals, or ammonium ions. A method for preparing the compound of chemical formula 1 comprises reductive amination of an aldehyde compound of chemical formula 2 and a phenylpiperazine compound of chemical formula 3.COPYRIGHT KIPO 2013본 발명은 신규의 1-페닐-4-(1,2,3-트리아졸-1-일알킬)피페라진 화합물, 이 화합물의 제조방법, 및 이 화합물을 유효성분으로 포함하는 도파민 D4 수용체에 선택적 활성을 가지는 약학적 조성물에 관한 것이다.
