Alonso Sarduy, Livan Bladimir,Lage Davila, Agustin Bienvenido,Perez Rodriguez, Rolando,Montero Casimiro, Jose Enrique
申请号：
AU2005306186
公开号：
AU2005306186B2
申请日:
2005.11.16
申请国别(地区):
AU
年份:
2012
代理人:
摘要：
The invention relates to pharmaceutical formulations which can be used in relation to cancer and which block the binding of Interleukin 2 (IL-2) to the receptor thereof. More specifically, the invention relates to therapeutic formulations that can increase the immunogenicity of IL-2 by coupling same to transport protein P64k of Neisseria meningitidis in adjuvant Montanide ISA 51 for the induction of autoantibodies that block the binding of IL-2 to the receptor thereof. The invention also relates to effective methods for the treatment of tumours, including breast cancer. The invention further relates to the therapeutic combination of the IL-2-based vaccine with other cancer vaccines based on specific antigens of tumours or tumour growth factors, as well as radiotherapy or chemotherapeutic medicaments that are traditionally used in oncological practice.
