With K opioid antagonist activity for use in the treatment of depressive disorder with characteristics menancolicas; combination of an opioid antagonist activity vortioxetina K and use for the same, and Pharmaceutical composition comprising an opioid antagonist with Act K and vortioxetina ivity.COMPOSICIÓN FARMACÉUTICA QUE COMPRENDE NALMEFENO O UNA SAL DEL MISMO, VORTIOXETINA O UNA SAL DEL MISMO Y UN EXCIPIENTE FARMACÉUTICAMENTE ACEPTABLE KIT ÚTIL PARA TRATAR UN TRASTORNO DEPRESIVO.