Paul Sweetnam;Yingfei Yang;Hope Foudoulakis;Alessandra Bartolozzi;Stewart Campbell;Enoch Kim
发明人:
Alessandra Bartolozzi,Stewart Campbell,Hope Foudoulakis,Enoch Kim,Paul Sweetnam,Yingfei Yang
申请号：
US11407500
公开号：
US08980915B2
申请日:
2006.04.19
申请国别(地区):
US
年份:
2015
代理人:
摘要：
The present invention relates to compounds which are inhibitors of microsomal triglyceride transfer protein and/or apolipoprotein B (Apo B) secretion. These compounds can be useful for the prevention and treatment of various diseases, particularly atherosclerosis and its clinical sequelae, for lowering serum lipids, and related ailments. The invention further relates to pharmaceutical compositions comprising the compounds and to methods of treating diseases, such as hypertriglyceridemia, hyperchylomicronemia, atherosclerosis, obesity, and related conditions using the compounds. A method for decreasing apolipoprotein B (apo B) secretion is also provided.
