МА Даншэ (US),ЦЗИНЬ Фан (US),ЧИСТЯКОВА Людмила Геннадьевна (US),САПРА Пуджа (US)
申请号：
RU2015116485
公开号：
RU2015116485A
申请日:
2013.10.30
申请国别(地区):
RU
年份:
2016
代理人:
摘要：
1. The selected antibody or its antigennegative fragment, which specifically bind to IL-13-Rα2 (receptor alpha 2 interleukin-13) of a person, where the antibody containing the variable region of the heavy chain and the variable region of the light chain includes (a) the variable region of the heavy chain containing CDR1 (complementarity determining region), CDR2 and CDR3, with SEQ ID NO: 1, and a light chain variable region containing CDR1, CDR2 and CDR3, with SEQ ID NO: 5； or (b) the variable region of the heavy chain containing CDR1, CDR2 and CDR3, with SEQ ID NO: 48, and the variable region of the heavy chain containing CDR1, CDR2 and CDR3, with SEQ ID NO: 41.2. An isolated antibody or antigen binding fragment thereof that specifically binds to human IL-13-Rα2, wherein the antibody contains (a) a heavy chain CDR1 comprising SEQ ID NO: 2； Heavy chain CDR2 comprising SEQ ID NO: 3； Heavy chain CDR3 comprising SEQ ID NO: 4； CDR1 light chain containing SEQ ID NO: 6； Light chain CDR2 comprising SEQ ID NO: 7； and CDR3 light chain containing SEQ ID NO: 8； or (b) a heavy chain CDR1 comprising SEQ ID NO: 10； Heavy chain CDR2 comprising SEQ ID NO: 11； Heavy chain CDR3 comprising SEQ ID NO: 12； CDR1 light chain containing SEQ ID NO: 14； CDR2 light chain containing SEQ ID NO: 15； and CDR3 light chain containing SEQ ID NO: 16.3. The isolated antibody or antigen binding fragment of claim 2, wherein said isolated antibody in (a) further comprises a heavy chain variable region with the amino acid sequence of SEQ ID NO: 1, and said isolated antibody in (b) further comprises a heavy chain variable region with SEQ ID NO: 48.4. An isolated antibody or antigen binding fragment thereof according to claim 2 or 3, wherein said isolated antibody in (a) further comprises a light chain variable region with the amino acid sequence of SEQ ID NO: 5, and said isolated antibody in (b) further comprises a light chain variable region with the amino acid sequence of SEQ ID NO: 41.5. Dedicated1. Выд
