Compositions and methods and provided for preventing or mitigating the effects of traumatic brain injuries, such as concussions. The compositions comprises between 100-11500 mg Docosahexaenoic acid (DHA), 100-3000 mg curcumin, and 100-3000 mg of resveratrol. The compositions may further include 100-3000 mg of α-linoleic acid. In some embodiments, the compositions may be administered to a subject prior to, during, or after a period of time wherein a traumatic brain injury may occur or may have occurred.
