The invention belongs to the field of medicine, and relates to medical application of arctigenin, in particular to application of the arctigenin in preparation of medicine for curing or preventing brain glioma. Preferably, the arctigenin is made into injection preparation. The dosage of the arctigenin for people is 0.1 mg / kg / day - 10 mg / kg / day. The arctigenin has the advantages of being precise in curative effect and low in toxic and side effect when used for curing or preventing brain glioma. Furthermore, the arctigenin enables clinical medication selection of a doctor to be further increased. Therefore, the arctigenin has a broad application prospect.