Antonio JIMENO,Yosef REFAELI,Xiao-Jing WANG,Dennis ROOP
申请号：
US14035780
公开号：
US20140109246A1
申请日:
2013.09.24
申请国别(地区):
US
年份:
2014
代理人:
摘要：
The present invention provides methods for the generation of xenochimaeric animals for example, xenochimaeric mice, comprising bone marrow progenitor cells and tumors from a heterologous animal. In some aspects, the invention provides xenochimaeric mice bearing humanized bone marrow and human tumors. Such animals are a model system for the study of human tumor stroma, for drug discovery, and for the treatment of human cancers.
