One Seed coffees coffee Leaf extracts and its extraction sides method With purposes, The extracts can press down base Quality gold Genus proteinase activities processed and/or generation, inhibition with what to be had Silk mitogen activated protein kinases phosphorylation and/or promotees the generation of Jin Rubber original albumen.一種咖啡葉萃取物及其萃取方法與用途,該萃取物可用於抑制基質金屬蛋白酶活性及/或生成、抑制有絲分裂原活化蛋白激酶磷酸化、及/或促進膠原蛋白生成。