Atsushi Hijikata;Fumihiko Ishikawa;Hiroshi Kitamura;Hidetoshi Ozawa;Yoriko Saito;Osamu Ohara;Leonard D. Shultz
发明人:
Fumihiko Ishikawa,Osamu Ohara,Yoriko Saito,Hiroshi Kitamura,Atsushi Hijikata,Hidetoshi Ozawa,Leonard D. Shultz
申请号：
US13258993
公开号：
US20120070450A1
申请日:
2010.03.24
申请国别(地区):
US
年份:
2012
代理人:
摘要：
The invention provides a test method for predicting the initial onset or a recurrence of acute myeloid leukemia (AML) comprising (1) measuring the expression level of human leukemic stem cell (LSC) marker genes in a biological sample collected from a subject for a transcription product or translation product of the gene as an analyte and (2) comparing the expression level with a reference value； an LSC-targeting therapeutic agent for AML capable of suppressing the expression of a gene selected from among LSC marker genes or a substance capable of suppressing the activity of a translation product of the gene； a method for producing a sample containing hematopoietic cells for autologous transplantation or allogeneic transplantation for AML patients comprising obtaining an LSC-purged sample with at least 1 kind of LSC marker as an index； and a method of preventing or treating AML.
