YANG, YOON SUN,양윤선,OH, WON IL,오원일,JEON, HONG BAE,전홍배,JUNG, MEE HYUN,정미현,JEONG, SANG YOUNG,정상영
申请号：
KR1020110122410
公开号：
KR1020120002506A
申请日:
2011.11.22
申请国别(地区):
KR
年份:
2012
代理人:
摘要：
PURPOSE: A TSP-1, TSP-2, IL-17BR and HB-EGF related to stem cell activity is provided to effectively promote differentiation of MSC into chondrocytes. CONSTITUTION: A composition for promoting differentiation of cells into chondrocytes contains cells expressing TSP-2(thrombospodin-2) or TSP-2 and pharmaceutically acceptabel carrier. The cells are UCB-MSC. The composition is used for treating or preventing cartilage damage, denaturation, deformity, or combination thereof. A method for differentiation of the cells into chondrocytes comprises a step of administering the composition into an individual. A composition for reducing chondrocyte apotosis contains heparin binding EGF-like growth factor(HB-EGF) or the stem cells and pharmaceutically acceptable carrier.하나이상의 구체예는, 줄기세포의 세포 활성과 연관된 TSP-1, TSP-2, IL-17BR 및 HB-EGF 및 이들의 용도를 제공한다.
