The present invention relates to an ophthalmic solution comprising 0.00001 to 10.0 weight percent of a simple saccharide, at least 0.00001 weight percent of a preservative, and not more than about 0.2 percent by weight chloride. The simple saccharide is chosen from the group consisting of: inositol mannitol sorbitol sucrose dextrose glycerin propylene glycol ribose triose tetrose erythrose threose pentose arabinose ribulose xylose xylulose lyxose hexose allose altrose fructose galactose glucose gulose idose mannose sorbose talose tagatose adlose ketose heptose sedoheptulose monosaccharides disaccharides sugar alcohols xylitol and polyol.