您的位置：
首页
>
农业专利
>
详情页
Quinolinas and quinoxalinas derivatives as inhibitors of protein tyrosine kinase
- 专利权人:
- NOVARTIS AG
- 发明人:
- FURET, PASCAL,GRAUS PORTA, DIANA,GUAGNANO, VITO
- 申请号：
- CU20100219
- 公开号：
- CU24001B1
- 申请日:
- 2010.11.12
- 申请国别(地区):
- CU
- 年份:
- 2014
- 代理人:
- 摘要：
- The Invention relates to quinolinas and quinoxalinas derivatives as inhibitors of protein tyrosine kinase of formulas: [5 - (4 - (piperazin-1-yl Ethyl methyl) pyridin-2-yl] - amide acid 8 - (2,6 - difluoro - 2.5 - dimethoxy phenyl) - quinoxalin - 5 carboxylic acid； 4 - (dimethyl amino methyl) - 1H imidazole - il - 2 Acid AMIDE) - 8 - (2,6 - difluoro - 25 - dimethoxy phenyl) - 5 - quinoxalin acid, 5 - (4 - methyl - piperazin-1-yl - methyl) - (pyridin-2-yl) - amide acid 8 - (2 - Chloro - 5 - fluoro - 3,5 - dimethoxy phenyl) - 5 - (quinoxalin - carboxylic acid and piperazin 1 - methyl - 5 - (pyridin-2-yl) - amide acid 8 - (2 - Chloro - 5 - fluoro - 3,5 - dimethoxy phenyl) - 5 - quinoxalin acid.In particular, for the treatment of diseases mediated by protein tyrosine kinase, such as cancer.La invención se refiere a los derivados de quinolinas y quinoxalinas como inhibidores de cinasa de proteína tirosina de fórmulas: [5-(4-etil-piperazin-1-il-metil)-piridin-2-il]-amida del ácido 8-(2,6-difluoro-2,5-dimetoxi-fenil)-quinoxalin-5-carboxílico； (4-dimetil-amino-metil-1H-imidazol-2-il)-amida del ácido 8-(2,6-difluoro-2,5-dimetoxi-fenil)-quinoxalin-5-carboxílico； 5-(4-metil-piperazin-1-il-metil)-piridin-2-il]-amida del ácido 8-(2-cloro-6-fluoro-3,5-dimetoxi-fenil)-quinoxalin-5-carboxílico y (5-piperazin-1-metil-piridin-2-il)-amida del ácido 8--(2-cloro-6-fluoro-3,5-dimetoxi-fenil)-quinoxalin-5-carboxílico. En particular para el tratamiento de enfermedades mediadas por proteína tirosina quinasa, tales como el cáncer.
- 来源网站：
- 中国工程科技知识中心
- 来源网址：
- http://www.ckcest.cn/home/
