And comprising the step of forming the skin tissue during the delivery opening one delivery one opening, a method of percutaneously delivered into the membrane of an animal the permeant substance, the about 40 to about 90 at least It has an average depth of the opening between the micron. The invention further relates to a method of delivering drugs transdermally biological membranes of the animal, comprising the step of forming a delivery plurality of openings through the membrane, where the invention, the method, the delivery opening The delivery opening has a mean opening depth of between about 90 microns and about 40, has a distribution resulting in a bell shaped curve.浸透体物質を動物の膜中へ経皮的に送達する方法は、少なくとも1つの送達開口部を皮膚組織中に形成する工程を包含し、この少なくとも1つの送達開口部は、約40~約90ミクロンの間の平均開口深度を有する。本発明は、さらに、動物の生体膜中に経皮的に薬物を送達する方法に関し、この方法は、膜を通る複数の送達開口部を形成する工程を包含し、ここで、前記送達開口部は釣鐘形曲線を生じる分布を有し、かつ前記送達開口部は約40~約90ミクロンの間の平均開口深度を有する。
