Douglas E. Brough,Joseph T. Bruder,C. Richter King,Marvin J. Grubman,John G. Neilan
申请号：
US12117513
公开号：
US08323663B2
申请日:
2008.05.08
申请国别(地区):
US
年份:
2012
代理人:
摘要：
The invention is directed to an adenoviral vector comprising at least one nucleic acid sequence encoding an aphthovirus antigen and/or a cytokine operably linked to a promoter. The adenoviral vector is replication-deficient and requires at most complementation of both the E1 region and the E4 region of the adenoviral genome for propagation. The invention also is directed to a method of inducing an immune response in a mammal comprising administering to the mammal a composition comprising the aforementioned adenoviral vector.
