NIAZI, KAYVAN,LAZAR, ADAM,LIU, PHILIP T.,SHIN, ANNIE,SIELING, PETER
申请号：
CA3067370
公开号：
CA3067370A1
申请日:
2018.06.15
申请国别(地区):
CA
年份:
2018
代理人:
摘要：
A pharmaceutical compositions and methods for immunotherapy are provided. Thepharmaceutical compositionincludes a genetically-engineered bacterium expressing a human disease-relatedantigen(s), preferably two or more patient-specific tumorantigens as a polytope. The bacterium has genetically engineeredlipopolysaccharide or a patients own endosymbiotic bacterium so thatthe bacterium expresses endotoxin at a low level, which is insufficient toinduce a CD-14 mediated sepsis. The genetically-engineeredbacterium can be administered to the patient, either systemically or locally,to induce tumor-specific immune response.
