PROBLEM TO BE SOLVED: To develop a technology to increase content uniformity for a general purpose without being limited to specific active ingredients.SOLUTION: Provided is a set of oral solid compositions containing 10 or more oral solid compositions as unit dosage forms, the oral solid composition comprising the following components (i) to (iii): (i) one or more polymers such as hydroxyalkylcellulose； (ii) one or more polymers such as alkyl cellulose； and (iii) active ingredients, and comprising particles having the properties of (a) to (d): (a) the active ingredient being contained within the particles； (b) the volume distribution average particle size being 1 to 900 nm； (c) the particles having the property that the contact angle of water on the particle film is 20-70 degrees； and (d) the particles being substantially free of surfactant, as well as the amount of the active ingredients in the oral solid composition being 10 mass% or less and having a content uniformity judgment value of less than 10%.SELECTED DRAWING: NoneCOPYRIGHT: (C)2020,JPO&INPIT【課題】特定の有効成分に限定されずに汎用的に含量均一性を高める技術を開発すること。【解決手段】１０個以上の経口固形組成物を単位剤形として含み、 前記経口固形組成物が、以下（ｉ）～（ｉｉｉ）の成分を含み、かつ（ａ）～（ｄ）の特性を有する粒子を含み：（ｉ）ヒドロキシアルキルセルロース等の１種以上のポリマー；（ｉｉ）アルキルセルロース等の１種以上のポリマー；ならびに（ｉｉｉ）有効成分；（ａ）有効成分が粒子内部に含まれる；（ｂ）体積分布平均粒子径が１～９００ｎｍである；（ｃ）前記粒子は、粒子膜上の水の接触角が２０～７０度であるという特性を有する；（ｄ）前記粒子は、界面活性剤を実質的に含まない； 前記経口固形組成物中の有効成分量が１０重量％以下であり、かつ１０％未満の含量均一性判定値を有する、経口固形組成物のセット。【選択図】なし
