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ФАРМАЦЕВТИЧЕСКАЯ КОМПОЗИЦИЯ ДЛЯ ПЕРОРАЛЬНОГО ВВЕДЕНИЯ ИНСУЛИНОВЫХ ПЕПТИДОВ
专利权人:
НОВО НОРДИСК А/С
发明人:
ФЁГЕР Флориан Андерс
申请号:
RU2012133075
公开号:
RU2012133075A
申请日:
2011.01.12
申请国别(地区):
RU
年份:
2014
代理人:
摘要:
1. A liquid pharmaceutical composition comprising at least one insulin peptide, at least one semi-polar protic organic solvent and at least two non-ionic surface-active compounds (surfactants) with HLB above 10, wherein such composition does not contain any oil or other the lipid component or surface-active compounds (surfactants) with HLB value below 7.2. The pharmaceutical composition of claim 1 which contains less than 10 wt.% Vody.3. The pharmaceutical composition of claim 1 which is nevodnoy.4. A pharmaceutical composition according to any one of the preceding claims, wherein the composition forms a micro- or nanoemulsion, after dilution in aqueous srede.5. A pharmaceutical composition according to claim 1, comprising two or three nonionic surfactants with an HLB above 10, while the remaining ingredients are excipients other than PAV.6. A pharmaceutical composition according to claim 1, wherein the semi-polar protic organic solvent is a protic solvent with a dielectric constant in the range of 20-50.7. A pharmaceutical composition according to claim 1, wherein the semi-polar protic organic solvent is glycerol or propilenglikol.8. The pharmaceutical composition of claim 1 which is in the form rastvora.9. A pharmaceutical composition according to claim 1, wherein one or more of the nonionic surfactants include fatty acid group with an average chain length, such as a C8 fatty acid (caprylate), C10-fatty acids (caprate) or C12-fatty acids (laurates) .10. A pharmaceutical composition according to claim 1, wherein one or more of the nonionic surfactants is selected from1. Жидкая фармацевтическая композиция, содержащая по меньшей мере один инсулиновый пептид, по меньшей мере один полуполярный протонный органический растворитель и по меньшей мере два неионных поверхностно-активных вещества (ПАВ) с ГЛБ выше 10, при этом такая композиция не содержит масла или любого другого липидного компонента или поверхностно-активного вещества (ПАВ) с ГЛБ ниже 7.2. Фармацевтическая ко
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