ARIADNA SELGA,BLANCA REYES,ISABEL AMAT RIERA,MERCÉ AMAT,PERE JOAN CARDONA IGLESIA
申请号：
BR112013017267
公开号：
BR112013017267A8
申请日:
2012.01.04
申请国别(地区):
BR
年份:
2018
代理人:
摘要：
The invention provides liposome formulations comprising fragments from a Mycobacterium tuberculosis-complex strain. It also provides a Mycobacterium tuberculosis-complex strain, fragments of which may be incorporated into selected embodiments of the liposome formulation. The invention further provides suspensions and pharmaceutical compositions comprising the liposome formulations. Furthermore, it discloses the use of the liposome formulations for use in a method of treatment of the human or animal body by therapy, in particular for use in a method of treating or preventing tuberculosis, such as in preventing latent tuberculosis or in tuberculosis prophylaxis, optionally in combination therapy. The formulation of this invention contains sucrose and/or has a lower average particle size than conventional liposome-based agents of tuberculosis therapy, resulting in higher bioavailability and efficiency.
