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METHOD FOR CONTROLLED RELEASE OF PARATHYROID HORMONE FROM ENCAPSULATED POLY(LACTIC-CO-GLYCOLICACID) MICROSPHERES
专利权人:
KAOHSIUNG MEDICAL UNIVERSITY
发明人:
HO, MEI LING,何美泠,何美泠,WANG, GWO JAW,王国照,王國照,CHANG, JE KEN,张瑞根,張瑞根,FU, YIN CHIH,傅尹志,傅尹志,TZENG, CHERNG CHYI,曾诚齐,曾誠齊,RAJALAKSHMANAN, ESWARAMOORTHY,路 卡曼,路 卡曼
申请号:
TW099130111
公开号:
TW201210610A
申请日:
2010.09.06
申请国别(地区):
TW
年份:
2012
代理人:
摘要:
The present invention provides a method for producing a controlled release microsphere with me an average size greater than 50 μm, comprising preparing a water-in-oil (w/o) emulsion comprising an inner aqueous layer containing a pharmaceutically effective amount of a biologically active polypeptide with activity similar to parathyroid hormone, and an oil layer containing a polymer substance of poly (lactic-co-glycolic acid) (PLGA), then adding the w/o emulsion into aqueous polyvinyl alcohol (PVA) solution to form a water-in-oil-in-water (w/o/w) double emulsion and then desorbing the solvent in the oil layer. The present invention also provides a controlled release microsphere prepared by the method and use thereof.本發明提供了一種生產平均粒徑大於50微米之控制釋放微小球的方法,包含製備一油包水〈w/o〉乳劑〈emulsion〉,其包含一層含有藥學上有效量生物活性多肽的內水層,該生物活性多肽之活性與副甲狀腺素類似,以及製備一含有聚乳酸-甘醇酸〈PLGA〉之聚合物的油層,接著將油包水乳劑加入聚乙烯醇〈PVA〉水溶液中以形成水包油包水〈water-in-oil-in-water,w/o/w〉雙乳劑〈double emulsion〉,然後再使油層中的溶劑脫附(desorb)。本發明同時也提供一個以此方法製備之控制釋放微小球及該微小球之用途。
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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