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Tau imaging probe
专利权人:
Yukitsuka Kudo;Shozo Furumoto;Nobuyuki Okamura
发明人:
Yukitsuka Kudo,Shozo Furumoto,Nobuyuki Okamura
申请号:
US13881872
公开号:
US09249101B2
申请日:
2011.10.28
申请国别(地区):
US
年份:
2016
代理人:
摘要:
An object of the present invention is to provide a probe for imaging a β-sheet structure protein which can be used for the diagnosis of conformational diseases, particularly disease (tauopathy) having a cardinal symptom such as intracerebral accumulation of tau protein, for example, Alzheimer's disease. Another object of the present invention is to provide a compound which is highly specific to tau and can image tau with satisfactory sensitivity, and also has high brain transition, low or non-recognized bone-seeking properties and low or non-recognized toxicity.According to the present invention, the above problems are solved by providing a compound of a formula I (wherein A, R1, R2, R3, R4, R5, R6, Ra and Rb are as defined in the present description) or a pharmaceutically acceptable salt or solvate thereof.
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