THE UNITED STATES OF AMERICA; AS REPRESENTED BY THE SECRETARY; DEPARTMENT OF HEALTH AND HUMAN SERVICES
发明人:
DONALD P. BOTTARO,FABIOLA CECCHI
申请号：
PT13720737
公开号：
PT2841087T
申请日:
2013.04.26
申请国别(地区):
PT
年份:
2017
代理人:
摘要：
The present invention provides variant VEGF polypeptides which have been altered in their C-terminal heparin binding region to lower their heparin binding affinity. These variants have been found to act as receptor antagonists for VEGF receptors and antagonize angiogenesis. These variants are useful to treat diseases characterized by pathological angiogenesis.
