PROBLEM TO BE SOLVED: To pursue temperature-induced glycolysis in the noninvasive measurement of glucose.SOLUTION: The change of glucose metabolism inside a skin nutrition capillary tube is induced, the change of localized reflectance optical signals in a plurality of distances between a light source and a detector and a plurality of wavelengths is measured as the function of the time of bringing a probe into contact with the skin, a time window capable of minimizing the influence of tissue and probe adaptation on signals is selected, and also the signals measured within the time window are used for the following calculation. One set of functions is calculated from a plurality of localized reflectance values in the plurality of distances between the light source and the detector and the plurality of wavelengths at a plurality of time intervals in at least two wavelengths within the time window, calibration relation between the combination of calculation functions and the glucose concentration of a living body is derived, and the calibration relation is used in order to predict the glucose concentration in body liquid in the following measurement.COPYRIGHT: (C)2007,JPO&INPIT【課題】グルコースの非侵襲性測定において温度誘発糖分解を追跡すること。【解決手段】皮膚栄養毛細管内のグルコース代謝の変化を誘発し、プローブを皮膚に接触させる時間の関数として、複数の光源検出器間距離及び複数の波長における局在反射率光信号の変化を測定し、信号に対する組織プローブ適応性の影響が最小限に抑えられる時間ウインドウを選択するとともに、時間ウインドウ内で測定された信号を後続の計算のために使用し、複数の光源検出器間距離での複数の局在反射率値と時間ウインドウ内でかつ少なくとも2つの波長における複数の時間間隔での複数の波長とから、一セットの関数を計算し、計算関数の組み合わせと生体のグルコース濃度との間の較正関係を導き出し、後続の測定で、体液中のグルコース濃度を予測するために較正関係を使用する。【選択図】 図1
