LEE, JUNG HWAN,이중환,CHAE, YOUNG CHAN,채영찬,KIM, YOUN DONG,김윤동,KANG, HYUN GU,강현구,IM, JONG HUN,임종훈,KIM, JONG IN,김종인,KIM, KI SEOK,김기석,JANG, SUNG KEY,장승기,OH, IL UNG,오일웅,CHOI, MIN JEONG,최민정,KANG, WOON JUN,강원준
申请号：
KR1020130002513
公开号：
KR1020130012140A
申请日:
2013.01.09
申请国别(地区):
KR
年份:
2013
代理人:
摘要：
PURPOSE: A DNA aptamer which specifically binds itself to a breast cancer-related Her2(ERBB2) receptor is provided to effectively suppress metastasis and to diagnose cancer.CONSTITUTION: An ERBB2 aptamer specifically binds itself to ERBB2 and has a base of sequence number 7. The ERBB2 aptamer additionally contains a sequence of sequence number 39 or 40 linked to 5 end and a sequence of sequence number 41 or 42 linked to 3 end. A pharmaceutical composition for treating cancer contains the ERBB2 aptamer as an active ingredient. The cancer includes breast cancer, colon cancer, lung cancer, gallbladder cancer, pancreatic cancer, or gastric cancer. A composition for diagnosing cancer contains the ERBB2 aptamer as an active ingredient.COPYRIGHT KIPO 2013본 발명은 유방암 관련 Her2 (ERBB2) 수용체에 특이적으로 결합하는 DNA 압타머, 이를 유효성분으로 함유하는 암전이 억제용 조성물 및 암진단용 조성물에 관한 것으로, 상기 압타머는 기존의 항체와는 다른 결합 기작을 가짐으로써 보다 효과적으로 암 전이를 억제하고 암을 진단할 수 있는 것을 특징으로 한다.
