Method of manufacturing wound dressing with aligned nano fibers having efficacies of anti-inflammatory, having good affinity for growth factors, and promoting wound healing
This invention relates to a method of manufacturing wound dressing with aligned nano fibers, comprising the steps of: a solution preparation step: taking polymer and curcumin powder to be dissolved in a mixed solvent of dimethylformamide and tetrahydrofuran to form polymer solution an electrospinning production step: utilizing high rotational speed roller of an electrospinning device to produce the polymer solution into aligned polymer nano fiber film containing curcumin and a surface modification step: grafting heparin to the surface of aligned polymer nano fiber film containing curcumin. With the method of this invention, a nano fiber wound dressing having efficacies of anti-inflammatory, having good affinity for growth factors, and promoting wound healing can be manufactured.一種順向性奈米纖維創傷敷材之製造方法,其步驟包括:溶液製備步驟:取高分子聚合物與薑黃素粉末溶於二甲基甲醯胺與四氫呋喃的混和溶劑中形成高分子溶液;電紡製成步驟:利用電紡裝置之高轉速滾輪將上述高分子溶液製成含有薑黃素的順向性高分子奈米纖維膜;表面修飾步驟:肝素接枝於含有薑黃素的順向性高分子奈米纖維膜表面,藉由本發明之方法能製造出具有抗發炎、對生長因子有良好的親和力及促進傷口癒合等功效之奈米纖維創傷敷材。101‧‧‧步驟102‧‧‧步驟103‧‧‧步驟
