Provided herein are methods , kits , and pharmaceutical compositions that include a PI3 kinase inhibitor for treating cancers or hematologic disorders. Provided herein are methods , compositions, and kits for treating or preventing cancers or diseases ,such as hematologic malignancies, which have a high expression level of one or more isoform (s) of PI3K (e.g., P13K -6 andPI3K-?). In one embodiment , the methods compositions , and kits provided herein relate to administering an isoform, selective PI3K modulator.